A safe and well tolerated pill to cure Hepatitis C, Elbasvir and Grazoprevir is a one- pill- once a day option for the treatment of genotype 1 or 4 infections. The presence of amino acid 28, 30, 31 or 93 substitutes requires the additional intake of ribavirin for the pill to work effectively and also an extended therapy from 12 to 16 weeks. It is oral fixed dose combination of NS5A replication complex inhibitor and a later generation HCV protease inhibitor. If we look at the activity against the HCV genotypes, these are better than the earlier generation protease inhibitors. Further, it is a result of the failures from the first- generation protease inhibitors.